Chemical Name: INDINAVIR (in-DIN-a-veer)
This medicine is an HIV protease inhibitor used in combination with other medicines to manage human immunodeficiency virus (HIV).
Some medicines or medical conditions may interact with this medicine. INFORM YOUR DOCTOR OR PHARMACIST of all prescription and over-the-counter medicine that you are taking. DO NOT TAKE THIS MEDICINE if you are also taking astemizole, cisapride, nevirapine, rifampin, sildenafil, terfenadine, or medicine for anxiety or sleep. ADDITIONAL MONITORING OF YOUR DOSE OR CONDITION may be needed if you are taking carbamazepine, sirolimus, tacrolimus, calcium channel blockers (e.g., amlodipine, felodipine), or St John's wort. Inform your doctor of any other medical conditions, including: history of kidney stones, allergies, pregnancy, or breast-feeding. Contact your doctor or pharmacist if you have any questions or concerns about taking this medicine.
Follow the directions for using this medicine provided by your doctor. Take this medicine on an empty stomach at least 1 hour before or 2 hours after eating. TAKE THIS MEDICINE WITH water. This medicine may be taken with other liquids such as skim milk, juice, coffee, or tea, or a light meal. DO NOT EAT GRAPEFRUIT OR DRINK GRAPEFRUIT JUICE AT ANY TIME WHILE TAKING THIS MEDICINE. DRINKING EXTRA FLUIDS while you are taking this medicine is recommended. You should drink at least 48 ounces of water a day unless otherwise directed by your doctor. Check with your doctor or nurse for instructions. STORE THIS MEDICINE in the original bottle. Do not store this medicine in the bathroom or other humid areas. IF YOU MISS A DOSE OF THIS MEDICINE, take it as soon as you remember. If it is within 2 hours of your next dose, skip the missed dose and go back to your regular dosing schedule. It is important not to miss doses of this medicine. DO NOT take 2 doses at once.
DO NOT EXCEED THE RECOMMENDED DOSE of this medicine without checking with your doctor. Exceeding the recommended dose of this medicine may not provide additional benefits, and may increase the risks of side effects. KEEP ALL DOCTOR AND LABORATORY APPOINTMENTS while you are taking this medicine. DO NOT STOP TAKING THIS MEDICINE without first checking with your doctor. THIS MEDICINE WILL NOT PREVENT YOU FROM SPREADING HIV through sexual contact. If you have any questions concerning how to prevent the spreading of HIV, ask your doctor, nurse, or pharmacist. THIS MEDICINE MAY NOT PREVENT OTHER INFECTIONS. If your health changes, check with your doctor. BEFORE YOU BEGIN TAKING ANY NEW MEDICINE, either prescription or over-the-counter, check with your doctor or pharmacist. DO NOT TAKE Seldane (terfenadine), Hismanal (astemizole), or cisapride while taking this medicine. IF YOU PLAN ON BECOMING PREGNANT, discuss with your doctor the benefits and risks of using this medicine during pregnancy. IT IS UNKNOWN IF THIS DRUG IS EXCRETED in breast milk. DO NOT BREAST-FEED while taking this medicine. IF YOU HAVE DIABETES, this medicine may affect your blood sugar. Check blood sugar levels closely and ask your doctor before adjusting the dose of your diabetes medicine.
Possible side effects
SIDE EFFECTS, that may go away during treatment, include side pain, stomach pain, weakness, nausea, vomiting, diarrhea, headache, or a bad taste in your mouth. If they continue or are bothersome, check with your doctor. CHECK WITH YOUR DOCTOR AS SOON AS POSSIBLE if you experience gradual onset of drowsiness, flushed face, fast heartbeat, chills, fever, unusual fatigue, thirst, loss of appetite, blood in urine, change in the amount of urine, pain while urinating, back or flank pain, yellowing eyes/skin, dry skin, cracked lips, loss of body hair, or ingrown toenails. Changes in body fat may occur while you are taking this medicine (e.g., increased fat in the upper back and stomach areas, decreased fat in the arms and legs). The cause and long-term effects of these changes are unknown. Discuss the risks and benefits of therapy with your doctor, as well as the possible role of exercise to reduce this side effect. If you notice other effects not listed above, contact your doctor, nurse, or pharmacist.
If you take too much
If overdose is suspected, contact your local poison control center or emergency room immediately. Symptoms of overdose may include lower back pain, blood in urine, nausea, vomiting, and diarrhea.
DO NOT SHARE THIS MEDICINE with others for whom it was not prescribed. DO NOT USE THIS MEDICINE for other health conditions. KEEP THIS MEDICINE out of the reach of children. IF USING THIS MEDICINE FOR AN EXTENDED PERIOD OF TIME, obtain refills before your supply runs out.